. 2016 Jun 17;11(6):e0157757. doi: 10.1371/journal.pone.0157757

Table 4. Comparison of the efficacies of colistin combinations vs monotherapies after 24 and 48 h of treatment^a.

Strain NO.	CST+MER VS CST		CST+TIG VS CST		CST+TIG VS TIG		CST+FOS VS CST		CST+FD VS CST		CST+RIF VS CST		CST+RIF VS RIF		CST+SUL VS CST		CST+SUL VS SUL
Strain NO.	Δlog^b	P value^c	Δlog	P value	Δlog	P value	Δlog	P value	Δlog	P value	Δlog	P value	Δlog	P value	Δlog	P value	Δlog	P value
24h of treatment
AB-1	-2.05	0.006	-0.94	0.009	-0.56	0.253	-1.14	0.007	-2.78	0.006	-2.95	0.006	-2.61	0.009	-0.08	0.955	-0.94	0.013
AB-2	-2.11	0.005	-0.91	0.008	-0.07	0.589	-1.16	0.006	-2.14	0.005	-2.96	0.005	-2.64	0.015	-0.08	0.861	-1.12	0.007
AB-3	-3.02	<0.001	0.08	0.162	0.00	0.448	-1.25	<0.001	-2.93	<0.001	-3.02	<0.001	-2.59	0.004	-0.32	0.002	-1.31	0.006
AB-4	-2.88	0.007	-1.26	0.009	-1.39	0.008	-2.06	0.033	-2.70	0.007	-3.34	0.007	-2.46	0.005	-0.43	0.018	-1.43	0.009
AB-5	-3.09	0.010	-1.47	0.011	0.16	0.335	-1.18	0.012	-2.70	0.010	-4.18	0.010	-2.74	0.004	-1.19	0.012	-0.87	0.003
AB-6	-0.91	0.008	0.16	0.169	-0.02	0.844	0.20	0.066	-1.84	0.006	-2.29	0.006	-2.40	0.004	0.03	0.951	-1.29	<0.001
AB-7	-0.46	0.012	-0.44	0.014	0.04	0.973	-0.65	0.007	-2.40	0.003	-2.41	0.003	-2.86	0.021	0.04	0.706	-1.32	0.004
AB-8	0.02	0.969	-0.54	0.053	-0.17	0.153	-0.95	0.032	-1.88	0.025	-2.71	0.024	-2.54	0.010	-0.18	0.225	-1.27	0.005
AB-9	-0.20	0.211	-0.42	0.105	-0.02	0.625	-0.73	0.063	-1.56	0.041	-3.11	0.039	-4.32	0.086	0.45	0.047	-1.63	0.004
AB-10	-0.17	0.096	-0.43	0.028	-0.80	0.071	-0.70	0.013	-1.75	0.007	-2.55	0.007	-3.47	0.012	0.36	0.003	0.42	0.760
AB-11	-0.44	0.078	-0.13	0.654	-0.91	0.052	-0.98	0.019	-2.08	0.014	-2.82	0.014	-2.92	0.030	-0.03	0.834	-0.65	0.004
AB-12	0.12	0.446	-0.67	0.022	-0.31	0.288	-1.03	0.014	-1.41	0.012	-2.90	0.011	-3.71	0.001	-0.16	0.196	-1.36	0.001
48h of treatment
AB-1	-2.02	0.002	-0.67	0.009	-0.31	0.399	-0.50	0.012	-2.87	0.002	-2.83	0.002	-3.49	0.008	-0.26	0.050	-2.00	0.014
AB-2	-2.04	0.002	-0.69	0.004	-0.66	0.013	-0.45	0.003	-2.63	0.002	-2.73	0.002	-2.65	0.001	-0.01	0.795	0.17	0.142
AB-3	-2.59	0.020	-0.47	0.056	-1.69	0.002	-0.54	0.045	-2.54	0.019	-2.78	0.019	-4.83	0.007	0.16	0.447	-2.04	0.014
AB-4	-2.93	0.010	-0.90	0.054	-1.77	0.009	-0.05	0.500	-4.04	0.009	-3.80	0.009	-5.58	0.024	-1.21	0.002	-1.60	0.041
AB-5	-2.35	0.011	-0.45	0.027	-0.42	0.009	-0.16	0.233	-2.91	0.011	-3.15	0.011	-3.01	0.001	0.02	0.997	-1.24	<0.001
AB-6	-0.11	0.985	-0.25	0.243	-0.92	0.005	0.12	0.150	-2.56	0.001	-2.95	0.001	-2.85	0.005	0.01	0.867	-0.88	0.001
AB-7	0.21	0.086	-0.40	0.010	-0.31	0.017	-0.33	0.017	-2.36	0.004	-2.94	0.004	-2.87	0.009	-0.02	0.993	-1.49	0.032
AB-8	0.30	0.053	-0.27	0.747	-0.18	0.989	-0.75	0.008	-1.89	0.004	-3.10	0.004	-3.91	0.010	-0.15	0.182	-0.16	0.096
AB-9	-0.23	0.117	-0.33	0.029	-1.21	0.001	-0.34	0.015	-1.44	0.004	-3.04	0.004	-3.17	0.001	-0.34	0.017	-1.50	0.002
AB-10	-0.28	0.110	-0.13	0.087	-0.11	0.474	-0.70	0.003	-2.95	0.002	-2.94	0.002	-5.15	0.007	-0.14	0.313	0.54	0.515
AB-11	-0.09	0.566	-0.12	0.860	-1.95	0.002	-0.71	0.015	-2.49	0.008	-2.96	0.008	-2.87	0.004	-0.07	0.629	0.01	0.905
AB-12	-0.04	0.870	0.12	0.535	-1.49	0.007	-0.25	0.109	-1.59	0.017	-3.34	0.016	-2.97	<0.001	-0.12	0.283	-0.88	0.004

^a CST, colistin; MER, meropenem; TIG, tigecycline; FOS, fosfomycin; FD, fusidic acid; RIF, rifampin; SUL, sulbactam.

^b Δlog means the log₁₀ recovered CFU of antibiotic combination therapy minus the log₁₀ recovered CFU of monotherapy.

^c A P value of < 0.05 indicates significance and is shown in bold.

Table 4. Comparison of the efficacies of colistin combinations vs monotherapies after 24 and 48 h of treatmenta.

Table 4. Comparison of the efficacies of colistin combinations vs monotherapies after 24 and 48 h of treatment^a.