Table 3. Enriched (DAVID Enrichment score ES > 2) functional clusters of Gene Ontology (GO) biological processes (BP) and molecular functions (MF) encompassing transcript isoforms differentially expressed between microglia and macrophages in wild type mice.
| Cluster1 | Representative GO Terms2 | ES |
|---|---|---|
| BP | cell adhesion; biological adhesion; cell-cell adhesion | 11.85 |
| MF | carbohydrate binding; pattern binding; polysaccharide binding | 8.07 |
| BP | response to wounding; inflammatory response; defense response | 6.67 |
| BP | cell motion; cell projection organization; neuron projection development | 5.93 |
| BP | cell motion; cell migration; localization of cell | 5.08 |
| MF, BP | GTPase regulator activity; nucleoside-triphosphatase regulator activity; regulation of small GTPase mediated signal transduction | 4.60 |
| BP | vasculature development; blood vessel development; blood vessel morphogenesis | 3.73 |
| BP | taxis; chemotaxis; locomotory behavior | 3.72 |
| BP | regulation of leukocyte proliferation; regulation of leukocyte activation; positive regulation of immune system process | 3.68 |
| MF | cytokine activity; chemokine activity; chemokine receptor binding | 3.3 |
| BP | positive regulation of immune system process; positive regulation of response to stimulus; immune response-regulating signal transduction | 3.26 |
| MF | guanyl ribonucleotide binding; guanyl nucleotide binding; GTP binding | 3.12 |
1 Each row corresponds to a cluster of Functional Annotation Tool (FAT) GO categories.
2 The three GO terms exhibiting most significant enrichment P-value within each cluster are listed, separated by “;”. Additional information in each cluster is provided in S3 Table.