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. 2016 Jun 17;11(6):e0157727. doi: 10.1371/journal.pone.0157727

Table 6. Differentially expressed genes (FDR-adjusted P-value < 0.001) between wild type (WT) and IDO1-knockout (IDO1-KO) mice within cell type, including log2(fold ratio) and supporting literature review reference.

Gene Symbol Gene Name Log2(WT/ IDO1-KO) Literature Review References
Microglia
Bcas1 breast carcinoma amplified sequence 1 2.32 [80]
Kif5a kinesin family member 5A 2.25 [81]
Mbp myelin basic protein 2.11 [82]
Mobp myelin-associated oligodendrocytic basic protein 1.87 [83]
Mid1 midline 1 1.61 [84]
Plekhb1 pleckstrin homology domain containing, family B (evectins) member 1 1.34 [85]
Kif5c kinesin family member 5C 1.17 [86]
S100b S100 protein, beta polypeptide, neural 1.09 [87]
Olig1 oligodendrocyte transcription factor 1 1.04 [88]
Stmn4 stathmin-like 4 1.04 [89]
Mog myelin oligodendrocyte glycoprotein 1.03 [88]
Tubb4a tubulin, beta 4A class IVA 0.97 [88]
Cldn11 claudin 11 0.95 [88]
Plp1 proteolipid protein (myelin) 1 0.94 [88]
Tmem88b transmembrane protein 88B 0.93 [88]
Gpr37 G protein-coupled receptor 37 0.93 [88]
Il33 interleukin 33 0.87 [7]
Cntn2 contactin 2 0.85 [88]
Efnb3 ephrin B3 0.83 [88]
Pllp plasma membrane proteolipid 0.80 [88]
Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 0.71 [57]
1810011O10Rik RIKEN cDNA 1810011O10 gene 0.66 [57]
Irg1, Cad immunoresponsive gene 1 -0.94 [57]
Gbp2 guanylate binding protein 2 -0.98 [90]
Oas3 2'-5' oligoadenylate synthetase 3 -1.14 [90]
Asprv1 aspartic peptidase, retroviral-like 1 -1.43 [91]
Cfb complement factor B -1.44 [57]
Lrg1 leucine-rich alpha-2-glycoprotein 1 -1.45 [88]
Plac8 placenta-specific 8 -1.58 [92]
Ifitm1 interferon induced transmembrane protein 1 -1.61 [7]
Pomc pro-opiomelanocortin-alpha -1.88 [57]
Steap4 STEAP family member 4 -2.28 [57]
Saa3 serum amyloid A 3 -3.32 [90]
Darc atypical chemokine receptor 1 (Duffy blood group) -4.21 [88]
Macrophages
Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 1.02 [93]
Rpl39 ribosomal protein L39 0.68 [92]
Arg1 arginase, liver -0.65 [94]
Ckap2l cytoskeleton associated protein 2-like -0.78 [92]
Sema3c sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.94 [92]
Pdpn podoplanin -0.97 [92]
Ifi205 interferon activated gene 205 -0.97 [90]
Phlda1 pleckstrin homology-like domain, family A, member 1 -0.99 [7]
Ccl2 chemokine (C-C motif) ligand 2 -1.03 [7]
Ch25h cholesterol 25-hydroxylase -1.11 [95]
Edn1 endothelin 1 -1.12 [92]
Prok2 prokineticin 2 -1.18 [93]
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 -1.22 [93]
F3 coagulation factor III -1.25 [90]
Slamf1 signaling lymphocytic activation molecule family member 1 -1.33 [7]
Steap4 STEAP family member 4 -1.34 [93]
Ccl5 chemokine (C-C motif) ligand 5 -1.45 [91]
Hba-a2 hemoglobin alpha, adult chain 2 -1.48 [91]
Ccrn4l CCR4 carbon catabolite repression 4-like -1.49 [92]
Il10 interleukin 10 -1.52 [7]
Hbegf heparin-binding EGF-like growth factor -1.52 [93]
Lipg lipase, endothelial -1.65 [92]
Ifih1 interferon induced with helicase C domain 1 -1.66 [92]
Rsad2 radical S-adenosyl methionine domain containing 2 -1.74 [92]
Ccl7 chemokine (C-C motif) ligand 7 -1.76 [90]
Tulp4 tubby like protein 4 -1.76 [93]
Isg15 ISG15 ubiquitin-like modifier -1.92 [92]
Csf2 colony stimulating factor 2 (granulocyte-macrophage) -2.46 [96]
Oasl1 2'-5' oligoadenylate synthetase-like 1 -2.74 [90]
Sele selectin, endothelial cell -3.04 [91]
Csf3 colony stimulating factor 3 (granulocyte) -3.53 [7]