Table 7. Enriched (DAVID Enrichment score ES > 2) functional cluster of categories encompassing transcript isoforms differentially expressed between IDO1-knockout and wild type mice within cell type.
| Cell Type and Category1 | Terms2 | Gene Count | P-value | ES |
|---|---|---|---|---|
| Microglia | ||||
| Cluster 1 | 2.61 | |||
| GO_BP_FAT | GO:0007272:Ensheathment of neurons | 5 | 4.64E-05 | |
| GO_BP_FAT | GO:0008366: Axon ensheathment | 5 | 4.64E-05 | |
| GO_BP_FAT | GO:0019228:Regulation of action potential in neuron | 5 | 8.20E-05 | |
| GO_BP_FAT | GO:0001508:Regulation of action potential | 5 | 1.68E-04 | |
| GO_BP_FAT | GO:0042391:Regulation of membrane potential | 6 | 3.64E-04 | |
| GO_BP_FAT | GO:0042552:Myelination | 4 | 8.97E-04 | |
| GO_BP_FAT | GO:0006873:Cellular ion homeostasis | 7 | 2.22E-03 | |
| GO_BP_FAT | GO:0055082:Cellular chemical homeostasis | 7 | 2.54E-03 | |
| GO_BP_FAT | GO:0050801:Ion homeostasis | 7 | 3.94E-03 | |
| GO_BP_FAT | GO:0019226:Transmission of nerve impulse | 6 | 6.13E-03 | |
| GO_BP_FAT | GO:0019725:Cellular homeostasis | 7 | 8.37E-03 | |
| GO_BP_FAT | GO:0048878:Chemical homeostasis | 7 | 1.12E-02 | |
| GO_BP_FAT | GO:0042592:Homeostatic process | 8 | 3.03E-02 | |
| GOTERM_MF_FAT | GO:0005198:Structural molecule activity | 5 | 1.91E-01 | |
| GOTERM_BP_FAT | GO:0050877:Neurological system process | 7 | 8.79E-01 | |
| Macrophages | ||||
| Cluster 1 | 8.39 | |||
| GOTERM_MF_FAT | GO:0005125:Cytokine activity | 18 | 3.16E-15 | |
| KEGG_PATHWAY | mmu04060:Cytokine-cytokine receptor interaction | 18 | 1.57E-10 | |
| GO_BP_FAT | GO:0006955:Immune response | 19 | 8.38E-09 | |
| KEGG_PATHWAY | mmu04630:Jak-STAT signaling pathway | 11 | 2.61E-06 | |
| GOTERM_BP_FAT | GO:0006952:Defense response | 13 | 1.08E-04 | |
| Cluster 2 | 3.35 | |||
| GOTERM_MF_FAT | GO:0008009:Chemokine activity | 6 | 5.36E-06 | |
| GOTERM_MF_FAT | GO:0042379:Chemokine receptor binding | 6 | 6.12E-06 | |
| GO_BP_FAT | GO:0009611:Response to wounding | 13 | 8.89E-06 | |
| GO_BP_FAT | GO:0006952:Defense response | 13 | 1.08E-04 | |
| GO_BP_FAT | GO:0006935:Chemotaxis | 7 | 1.50E-04 | |
| GO_BP_FAT | GO:0042330:Taxis | 7 | 1.50E-04 | |
| GO_BP_FAT | GO:0006954:Inflammatory response | 8 | 1.35E-03 | |
| KEGG_PATHWAY | mmu04621:NOD-like receptor signaling pathway | 5 | 3.61E-03 | |
| GO_BP_FAT | GO:0007626:Locomotory behavior | 7 | 8.39E-03 | |
| GO_BP_FAT | GO:0007610:Behavior | 9 | 9.96E-03 | |
| KEGG_PATHWAY | mmu04062:Chemokine signaling pathway | 7 | 1.05E-02 | |
| KEGG_PATHWAY | mmu04620:Toll-like receptor signaling pathway | 5 | 1.84E-02 | |
| Cluster 3 | 2.40 | |||
| GO_BP_FAT | GO:0001944:Vasculature development | 9 | 5.08E-04 | |
| GO_BP_FAT | GO:0001568:Blood vessel development | 8 | 2.14E-03 | |
| GO_BP_FAT | GO:0048514:Blood vessel morphogenesis | 7 | 3.40E-03 | |
| GO_BP_FAT | GO:0044057:Regulation of system process | 6 | 1.64E-02 | |
| GO_BP_FAT | GO:0001525Angiogenesis | 5 | 1.67E-02 | |
| Cluster 4 | 2.24 | |||
| GO_BP_FAT | GO:0030335:Positive regulation of cell migration | 5 | 1.51E-04 | |
| GO_BP_FAT | GO:0051272:Positive regulation of cell motion | 5 | 2.27E-04 | |
| GO_BP_FAT | GO:0040017:Positive regulation of locomotion | 5 | 2.99E-04 | |
| GO_BP_FAT | GO:0030334:Regulation of cell migration | 5 | 4.70E-03 | |
| GO_BP_FAT | GO:0051270:Regulation of cell motion | 5 | 7.99E-03 | |
| GO_BP_FAT | GO:0040012:Regulation of locomotion | 5 | 8.79E-03 | |
| GO_BP_FAT | GO:0007155:Cell adhesion | 5 | 5.97E-01 | |
| GO_BP_FAT | GO:0022610:Biological adhesion | 5 | 5.98E-01 | |
1 Each row corresponds to a Functional Annotation Tool (FAT) GO category inside a cluster.
2 GO terms inside each cluster.