Table 3. Summary of CDKL5/Cdkl5 nomenclature.
| New isoform nomenclature | Coding region sizes | |||||
|---|---|---|---|---|---|---|
| Human | Mouse | (bp) | (aa) | Former name | Ensembl transcript | Descriptive name |
| hCDKL5_1 | mCdkl5_1 | 2883 | 960 | CDKL5107 | CDKL5-005/Cdkl5-003 | hCDKL5_2–19Δ17 |
| hCDKL5_2 | mCdkl5_2 | 3006 | 1001 | CDKL5-16b | - | hCDKL5_2–19 |
| hCDKL5_3 | - | 2832 | 943 | - | - | hCDKL5_2-19s11Δ17 |
| hCDKL5_4 | - | 2955 | 984 | - | - | hCDKL5_2-19s11 |
| hCDKL5_5 | - | 3093 | 1030 | CDKL5115 | CDKL5-002 | hCDKL5_2–22 Δ17s19 |
| - | mCdkl5_6 | 2769 | 923 | - | - | mCdkl5_2–21 Δ17s19 |
| - | mCdkl5_7 | 2796 | 931 | - | - | mCdkl5_2–21 Δ17s19Δ20 |
| - | mCdkl5_8 | 2817 | 938 | CDKL5105 | Cdkl5-001 | mCdkl5_2–22 Δ17s19Δ20Δ21 |
The new proposed nomenclature system, former names, equivalent Ensembl transcript model and coding region sizes. The descriptive name indicates, in addition to the major coding isoform, the variable exon usage associated with each transcript: Δ indicates that an exon is not used; s indicates that the short form of the exon is used, where an alternative splice site is present.