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. Author manuscript; available in PMC: 2016 Jun 17.
Published in final edited form as: Cell Mol Bioeng. 2016 Feb 18;9(2):252–257. doi: 10.1007/s12195-016-0431-1

Figure 1.

Figure 1

Figure shows the outer nuclear membrane (ONM) and the inner nuclear membrane (INM) maintained at 45+/−5 nm (adapted from Chang et al., 2015). The SUN protein is a trimer that is embedded on the N terminal side in the INM and binds to KASH domain containing proteins embedded in the ONM. These link to the cytoskeleton. SUN and KASH proteins have been proposed to be responsible for maintaining the distance at 45 nm, although the mechanism is unclear.