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. 2015 Nov 13;94(45):e2030. doi: 10.1097/MD.0000000000002030

FIGURE 1.

FIGURE 1

Possible signaling mechanisms underlying miRNAs action with the examples of miR31 and miR-21. A, a signal transduction feedback loop, in which miR-31 and NF-κB play a key role, has been delineated. This feedback loop contributes to inflammatory responses and skin phenotype of psoriasis. B, a complex network formed by miR-21 activity and STAT3 activation contributes to keratinocytes proliferation in psoriasis. The detailed information of these signals is seen in the related body text. AP-1 =  Jun/activating protein 1; CXCLs = chemokine (C-X-C motif) ligands; FIH-1 = factor-inhibiting hypoxia-inducible factor 1; IL = interleukin; NF-κB = nuclear factor κB; ppp6c = protein phosphatase 6c; P2X7R = receptor of purinergic recepter p2x, ligand-gated ion channel,7; STAT3 = signal transducer and activator of transcription 3; TGF-β1 =  transforming growth factor β1; Th17 = T helper type-17; VEGF = vascular endothelial growth factor.