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. 2016 Jun 13;29(6):832–845. doi: 10.1016/j.ccell.2016.04.014

Figure 1.

Figure 1

CXCR2 Expression at the Tumor Border Is Associated with Poor Outcome in Human PDAC

(A) Expression of CXCR2 and its ligands in the tumor border compared with adjacent normal pancreas within pancreaticoduodenectomy specimens (n = 44). RNA was prepared from whole targeted biopsies of the edges of tumors, post-resection, and from adjacent normal pancreas. p Values, Mann-Whitney U test.

(B) Kaplan-Meier analysis of survival in terms of low or high CXCR2 and CXCL2 expression from RNA from whole targeted biopsies of the edges of resected tumors. p Values, log rank test.

(C) Kaplan-Meier analysis of survival in terms of low or high CXCR2 expression as assessed by IHC on full-face sections of tumor border regions (n = 11). p Values, log rank test.

(D) IHC staining for CXCR2, MPO, CD68, and CD3 in the stroma at the edge of resected tumors. Arrowheads indicate direction of invasion into either adjacent duodenum or normal pancreas. Scale bars represent 500 μm. Boxplots below show quantification of cells staining positive for each marker in the tumor center versus tumor border (n ≥ 3). p Values, Mann-Whitney U test. The region 1 mm proximal to the adjacent normal tissue was assessed in (C and D). See also Figure S1.