Table 1. Phenotypic responses of 25 inbred strains to infection with P. chabaudi chabaudi AS.
Twenty five commonly used inbred strains from the Jackson Phenome Database were phenotyped for susceptibility to P. chabaudi chabaudi AS infection. Mice were infected i.p. with 106 parasitized RBC and parasitemia (expressed as percentage of parasitized RBC) and survival were assessed daily following infection. Mean peak parasitemia levels are indicated ± SD. Resistance or susceptibility status was based on overall survival.
| Strain | # of mice (M,F) | Peak Parasitemia (%pRBC) | Survival (%) | ||||
|---|---|---|---|---|---|---|---|
| Males | Females | Males | Females | ||||
|
| |||||||
| C57BL/6J | (5,5) | 43±4 | 31±7 | 100 | R | 100 | R |
| 129S1/SvlmJ | (4,4) | 56±2 | 41±4 | 100 | R | 100 | R |
| FVB/NJ | (5,5) | 61±5 | 48±4 | 80 | R | 100 | R |
| DBA/1LacJ | (0,5) | ND | 48±3 | ND | 100 | R | |
| RBF/DnJ | (5,0) | 56±4 | ND | 80 | R | ND | |
| NZB/BINJ | (5,0) | 67±6 | ND | 80 | R | ND | |
|
| |||||||
| BALB/cJ | (5,5) | 51±10 | 41±6 | 0 | S | 100 | R |
| DBA/2J | (4,4) | 58±6 | 43±3 | 0 | S | 100 | R |
| AKR/J | (5,5) | 61±4 | 51±2 | 0 | S | 100 | R |
| BTBRT+tf/J | (4,4) | 72±6 | 68±4 | 0 | S | 100 | R |
| CBA/J | (5,5) | 65±6 | 57±9 | 40 | I | 60 | I |
| PL/J | (5,0) | 49±7 | ND | 40 | I | ND | |
| BALB/cByJ | (4,4) | 54±9 | 69±4 | 50 | I | 0 | S |
| A/J | (10,10) | 60±8 | 52±7 | 0 | S | 50 | I |
|
| |||||||
| SM/J | (5,5) | 62±13 | 60±7 | 20 | S | 20 | S |
| KK/HIJ | (4,4) | 59±4 | 51±3 | 0 | S | 0 | S |
| NOD/LtJ | (5,0) | 63±5 | ND | 0 | S | ND | |
| MRL/MpJ | (5,5) | 63±5 | 61±3 | 0 | S | 0 | S |
| CAST/EiJ | (4,4) | 69±3 | 56±4 | 0 | S | 0 | S |
| SJL/J | (0,5) | ND | 57±4 | ND | 0 | S | |
| SWR/J | (5,5) | 70±1 | 70±4 | 0 | S | 0 | S |
| C3H/HeJ | (5,5) | 71±5 | 66±9 | 0 | S | 0 | S |
| NZW/LacJ | (5,5) | 72±4 | 68±5 | 0 | S | 0 | S |
| NU/J | (0,5) | ND | 73±3 | ND | 0 | S | |
| C3HeB/FeJ | (5,5) | 72±2 | 70±5 | 0 | S | 0 | S |
R = resistant; I = intermediate; S = susceptible; ND = not determined