Table 2.

Study Sample Characteristics

Study Sample	N (% Female)	Design	Pain Stimulus	Threshold Comparison	Tolerance Comparison
Fertig et al. (1986)-a [31] Fertig et al. (1986)-b [31]	10sm (0) 15e-sm (0)	Within	Cold Pressor	Smoke + Snuff vs. Zero-Nic Cig + Sham¹,² Snuff vs. Zero-Nic Snuff	Smoke + Snuff vs. Zero-Nic Cig + Sham¹,² Snuff vs. Zero-Nic Snuff

Jamner et al. (1998)-a [45] Jamner et al. (1998)-b [45] Jamner et al. (1998)-c [45] Jamner et al. (1998)-d [45]	21sm (0) 17sm (0) 23n-sm (0) 13sm (0)	Within	Heat	Nic Patch vs. Zero-Nic Patch	Nic. Patch vs. Zero-Nic Patch

Jarvik et al. (1989) [46]	15sm (27)	Within	Cold Pressor	No Data Reported	Smoke vs. Deprived

Kanarek & Carrington (2004) [47]	49sm (51)	Within	Cold Pressor	Smoke vs. No Smoke	Smoke vs. No Smoke

Lane et al. (1995) [48]	18sm (49)	Within	Heat	Smoke vs. Abstinence	Smoke vs. Abstinence

Nastase et al. (2007)-a [57] Nastase et al. (2007)-b [57]	11sm (100) 12sm (0)	Within	Cold Pressor	Smoke vs. No Smoke	Smoke vs. No Smoke

Nesbitt (1973) [58]	30sm (0)	Within	Electrical	Not Tested	Smoke vs. Sham¹

Pauli et al. (1993) [63]	9sm (0)	Within	Heat	Pre-Post Smoking	Not Tested

Perkins et al. (1994)-a [64] Perkins et al. (1994)-b [64]	10sm (0) 10n-sm (0)	Between	Heat	Pre-Post Nic Spray	Not Tested
Perkins et al. (1994)-c [64] Perkins et al. (1994)-d [64]	12sm (50) 12n-sm (50)	Between	Heat	Nic vs. Zero Nic Spray (pre-post)	Not Tested
Perkins et al. (1994)-e [64] Perkins et al. (1994)-f [64]	18sm (50) 18n-sm (50)	Between	Heat	Nic vs. Zero Nic Spray (pre-post)	Not Tested

Pomerleau et al. (1984) [66]	5sm (0)	Within	Cold Pressor	Smoke vs. Zero Nic Cig	Smoke vs. Placebo

Shiffman & Jarvik (1984) [71]	10sm (80)	Within	Electrical	Smoke vs. Sham¹	Not Tested

Silverstein (1982) [73]	20sm (0)	Between	Electrical	Smoke vs. No Smoke	Smoke vs. No Smoke

Unrod et al. (2004) [78]	80sm (50)	Between	Cold Pressor	Smoke vs. No Smoke	Smoke vs. No Smoke

Notes. Sham = simulated smoking using an unlit cigarette;

data within each condition was collapsed across both manipulations. Between = between-subjects design; Cig = cigarette; e-sm = ex-smoker; Nic. = Nicotine; n-sm = non-smoker; sm = smoker; Within = within-subjects design.