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. Author manuscript; available in PMC: 2016 Nov 30.
Published in final edited form as: Nat Chem Biol. 2016 May 30;12(7):552–558. doi: 10.1038/nchembio.2089

Figure 4. Sigma-1 is a functional target of finazine.

Figure 4

(a) Chemical structure of known sigma-1 ligands: (+)-SKF-10,047 (28), cutamesine (29), phencyclidine (30), noscapine (31), eliprodil (32) and donepezil (33). (b) Dose curves showing the degree of behavioral switching, measured by the freezing index. Data represent mean ± s.d. for n = 12 wells per dose and are representative of three independent experiments. (c) Full-range boxplots showing all data from n = 12 wells of wild-type sibling (WT) or homozygous mutant sigmar1 fish (8 or +25) treated with 10 μM scopolamine and either DMSO (−), 5 μM finazine or 10 μM cutamesine. Boxes represent the interquartile range, whiskers represent maximum and minimum values. Data are representative of two independent experiments. (d) Same as (c), but with wild-type sibling (WT) or homozygous mutant pgrmc1 fish (+8). Statistical significance was calculated using a student’s t-test (2-tailed, unpaired, unequal variance).