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Interactions with cognate and non-cognate substrates. (A). F282 plays a critical role in the recognition of VEID (yellow sticks) by variant caspases. In V4, Loop 4 is reoriented when bound to VEID. (B). Few conformational changes are observed upon binding of the esCaspases to DEVD (green sticks). Figures show superpositions resulting from alignment of the substrate atoms.
