Fig. 1.

The expression of TOB1 mRNA in CD4⁺ T cells from CIS patients. The expression of TOB1 was assessed by RT-PCR in naïve (black) and total (grey) CD4⁺ T cells from healthy controls, CIS patients within 3 months of their initial episode and RRMS patients within 2 months of a clinically confirmed relapse who had previously converted to CDMS within 1 year. CIS patients were subsequently divided into those who converted to CDMS within 1 year (CISc) and those that did not convert (CISnc). All values are expressed relative to those of healthy controls averaged and set to 1. Statistical differences between groups were determined by two-way ANOVA with a Tukey post-test, however, results were not significantly different