Table 5. Cox model predictors of overall survival of MSS tumours (N=407).

Covariable	N	Model 1		Model 2		Model 3		Model 4
		HR	P-value	HR	P-value	HR	P-value	HR	P-value
APC	296	0.65	0.021	0.56	0.008	0.49	0.001	0.59	0.006
KRAS	179	1.62	0.007
TP53	261	1.41	0.056
BRAF	18	2.63	0.002	2.38	0.005	2.23	0.011	2.25	0.011
AKP	85			1.79	0.005	1.43	0.090
Two APC mut	116			1.29	0.217	1.58	0.027
APC(2)KP	40							2.10	0.003
Metastasis	155					4.55	<0.0001	4.49	<0.0001
Age (⩾70)	131	1.05	0.005	1.04	0.008	1.09	<0.0001	1.09	<0.0001
LR χ2	407	29.7	<0.0001	28.9	<0.0001	98.5	<0.0001	97.9	<0.0001

APC, Adenomatous polyposis coli; HR, hazards ratio; LR, likelihood ratio.