Table 2.

Associations between CD44 expression and OS of HCC grouped by selected factors

Stratified analysis	Studies	Odds ratio		Model	Heterogeneity
		OR (95 % CI)	POR		I2 (%)	P
OS	15	1.49 (1.26–1.76)	<0.00001	Random	74	<0.00001
Method
IHC	13	1.48 (1.22–1.78)	<0.0001	Random	76	<0.00001
RT-PCR	2	1.64 (1.32–2.04)	<0.0001	Fixed	0	0.99
Cut off
>10 %	3	1.63 (1.05–2.54)	0.03	Random	55	0.11
≤10 %	10	1.45 (1.17–1.80)	0.0007	Random	80	<0.00001
Median	2	1.64 (1.32–2.04)	<0.0001	Fixed	0	0.99
Sample size
>50	11	1.38 (1.17–1.64)	0.0002	Random	75	<0.0001
≤50	4	2.26 (1.64–3.12)	<0.00001	Fixed	30	0.23
Follow-up(m)
>60	8	1.53 (1.22–1.92)	0.0002	Random	74	0.0004
≤60	7	1.46 (1.12–1.90)	0.005	Random	76	0.0004
Subtypes of the CD44 family
CD44	4	1.35 (1.16–1.56)	0.0001	Fixed	24	0.27
CD44v6	6	1.51 (1.11–2.05)	0.008	Random	86	<0.00001
CD44s	5	1.59 (1.10–2.29)	0.01	Random	74	0.004

POR P value for odds ratio