Table 1.

Relationships of the PIK3CA E545K mutation with the clinicopathological characteristics of the GBCs

Parameter	Category	No.of cases	PI3K E545K mutation status
			No.of positive cases (%)	χ2	P value
Age	<60	60	3 (5 %)	0.020	0.888
	≥60	70	5 (7.14 %)
Gender	Male	61	3 (4.92 %)	0.034	0.853
	Female	69	5 (7.25 %)
Lymph node metastasis	Negative	86	4 (4.65 %)	0.373	0.541
	Positive	44	4 (9.09 %)
TNM stage	II	8	0 (0 %)	(a)	0.352
	III	101	6 (5.94 %)
	IV	21	2 (9.52 %)
Margin status	R0	71	5 (7.04 %)	0.009	0.924
	R1	59	3 (5.08 %)
Jaundice	Negative	91	6 (6.59 %)	0.000	1.000
	Positive	39	2 (5.13 %)

(a) The TNM stage data did not meet the criterion for χ2 analysis, thus, we used a Spearman rank correlation analysis