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. 2016 Jun 18;17:73. doi: 10.1186/s12931-016-0387-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — (a) FEV₁ AUC_0–3 and trough FEV₁ responses, (b) SGRQ total score and (c) TDI focal score: treatment comparisons at 12 weeks for T + O 5/5 μg versus T 5 μg and versus placebo in patients who were treatment naive/not treatment naive at baseline. FEV₁: forced expiratory volume in 1 s; AUC_0–3: area under the curve from 0–3 h; SGRQ: St George’s Respiratory Questionnaire; TDI: Transition Dyspnoea Index; T: tiotropium; O: olodaterol; CI: confidence interval