Table 3.
Risk of breast cancer according to BMI and mammographic measures, by detection mode and tumor size
| OPERA (95 % CI) | ||||||||
|---|---|---|---|---|---|---|---|---|
| BMI | BMI + DA + NDA | BMI + PDA | BMI + DA | DA + NDA | PDA | DA | ||
| Screen-detected, small tumors | BIC, AUC | 516, 0.64 | 528, 0.65 | 521, 0.65 | 521, 0.65 | 521, 0.62 | 515, 0.62 | 515, 0.62 |
| (192 cases/552 controls) | BMI per 1 SD | |||||||
| At age 50 years | 0.91 (0.64, 1.31) | 0.92 (0.64, 1.33) | 0.93 (0.65, 1.33) | 0.93 (0.65, 1.33) | ||||
| At age 70 years | 1.32 (1.07, 1.62) | 1.32 (1.08, 1.62) | 1.32 (1.07, 1.62) | 1.32 (1.07, 1.62) | ||||
| P for interactiona | 0.10 | 0.11 | 0.12 | 0.12 | ||||
| DA per adjusted 1 SD | 1.09 (0.93, 1.28) | 1.10 (0.93, 1.29) | 1.08 (0.92, 1.28) | 1.09 (0.93, 1.28) | ||||
| PDA per adjusted 1 SD | 1.12 (0.94, 1.32) | 1.11 (0.94, 1.31) | ||||||
| NDA per adjusted 1 SD | 0.96 (0.82, 1.13) | 0.97 (0.82, 1.14) | ||||||
| Screen-detected, large tumors | BIC, AUC | 145, 0.60 | 147, 0.69 | 142, 0.69 | 142, 0.69 | 136, 0.69 | 132, 0.69 | 132, 0.69 |
| (49 cases/141 controls) | BMI per 1 SD | |||||||
| At age 50 years | 0.78 (0.32, 1.92) | 0.83 (0.32, 2.14) | 0.83 (0.33, 2.10) | 0.79 (0.30, 2.07) | ||||
| At age 70 years | 1.14 (0.71, 1.83) | 1.09 (0.64, 1.84) | 1.10 (0.65, 1.85) | 1.11 (0.66, 1.87) | ||||
| P for interactiona | 0.49 | 0.65 | 0.63 | 0.56 | ||||
| DA per adjusted 1 SD | 1.56 (1.12, 2.19) | 1.58 (1.12, 2.22) | 1.57 (1.12, 2.20) | 1.59 (1.13, 2.24) | ||||
| PDA per adjusted 1 SD | 1.64 (1.13, 2.38) | 1.66 (1.14, 2.40) | ||||||
| NDA per adjusted 1 SD | 0.85 (0.58, 1.24) | 0.84 (0.57, 1.22) | ||||||
| Interval cases, small tumors | BIC, AUC | 217, 0.62 | 208, 0.74 | 203, 0.74 | 211, 0.70 | 199, 0.73 | 194, 0.73 | 203, 0.69 |
| (76 cases/224 controls) | BMI per 1 SD | |||||||
| At age 50 years | 0.76 (0.43, 1.32) | 0.68 (0.37, 1.25) | 0.68 (0.37, 1.24) | 0.70 (0.38, 1.26) | ||||
| At age 70 years | 0.88 (0.54, 1.43) | 0.96 (0.58, 1.57) | 0.93 (0.57, 1.51) | 0.89 (0.55, 1.46) | ||||
| P for interactiona | 0.73 | 0.46 | 0.49 | 0.58 | ||||
| DA per adjusted 1 SD | 1.65 (1.22, 2.23) | 1.64 (1.22, 2.21) | 1.61 (1.20, 2.17) | 1.60 (1.20, 2.15) | ||||
| PDA per adjusted 1 SD | 1.99 (1.43, 2.77) | 1.94 (1.40, 2.68) | ||||||
| NDA per adjusted 1 SD | 0.65 (0.48, 0.86) | 0.65 (0.49, 0.86) | ||||||
| Interval cases, large tumors | BIC, AUC | 196, 0.59 | 163, 0.82 | 159, 0.82 | 167, 0.79 | 152, 0.82 | 148, 0.82 | 156, 0.79 |
| (65 cases/204 controls) | BMI per 1 SD | |||||||
| At age 50 years | 1.23 (0.67, 2.23) | 0.99 (0.52, 1.87) | 0.95 (0.51, 1.78) | 0.99 (0.52, 1.89) | ||||
| At age 70 years | 1.11 (0.73, 1.70) | 0.92 (0.54, 1.57) | 0.94 (0.55, 1.60) | 0.94 (0.58, 1.53) | ||||
| P for interactiona | 0.83 | 0.89 | 0.98 | 0.91 | ||||
| DA per adjusted 1 SD | 2.77 (1.86, 4.14) | 2.73 (1.87, 4.00) | 2.74 (1.85, 4.05) | 2.70 (1.86, 3.92) | ||||
| PDA per adjusted 1 SD | 3.49 (2.19, 5.56) | 3.43 (2.18, 5.41) | ||||||
| NDA per adjusted 1 SD | 0.58 (0.40, 0.83) | 0.58 (0.40, 0.83) | ||||||
All of the estimates from conditional logistic regression were adjusted for age at mammogram and the variables included into the model. AUC area under the receiver operating characteristic curve, BIC Bayesian information criterion, BMI body mass index, CI confidence interval, DA dense area, NDA non-dense area, OPERA odds per adjusted standard deviation, PDA percent dense area, SD standard deviation. aLikelihood ratio test for the interaction with age at diagnosis