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. 2016 Jun 18;18:143. doi: 10.1186/s13075-016-1042-x

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Interleukin (IL)-33 expression and promoter activation in the skin during imiquimod (IMQ)-induced skin inflammation. Immunofluorescence staining for IL-33 in skin samples 11 days after daily IMQ or Vaseline application. IMQ-treated IL-33^-/- mice showed no expression of IL-33 (a), whereas IMQ-treated wild-type (WT) mice showed IL-33 expression (red) in keratinocyte nuclei (b) as did WT mice without IMQ treatment (c). On the bottom panel, the activity of the endogenous IL-33 promoter, by X-Gal staining, showed IMQ-treated IL-33^-/- mice with expression in basal layers of the epidermis (d) and no detection in WT mice (e) (×200)