Table III.

Population Attributable Fraction (PAF) of Depressive Symptoms in MSM and Transgender Women.

Population level impact of severe depression on adherence to PrEP.

		Baseline Prevalence	Marginal Probability of Insufficient Adherence%	Odds Ratio*	Population Attributable Fraction#
	CES-D < 16	0.73	0.6	--	--
MSM	16 ≤ CES-D < 27	0.2	0.5	0.6	−0.03+
	27 ≤ CES-D	0.07	0.74	2.44	0.01
	CES-D < 16	0.61	0.59	--	--
TGW	16 ≤ CES-D < 27	0.24	0.74	2.56	0.07
	27 ≤ CES-D	0.16	0.69	1.82	0.03

^%Marginal probability of insufficient adherence

^*Odds of not having sufficient drug levels for full protection

^#Population attributable fraction represents the proportion of non-adherence that would be resolved if an intervention were to move all CES-D scores to the lowest category while holding all else constant.

⁺Negative value reflects the fact that adherence was highest among those with CES-D scores corresponding to mild-moderate depressive symptoms