Author response image 1. Results of the validation simulations.
(A) The fitting error was substantially smaller if we used similar presynaptic parameters to fit the validation data than the true parameters used to generate the data. In this case the fitting error was essentially zero since there is no intrinsic variability in the artificial data. (B) The error in the postsynaptic parameters (number of cells targeting the dendritic branch, and the postsynaptic filtering time constant) is substantially smaller when the true presynaptic parameters match those used for fitting the model (blue) than when the parameters are mismatched.