Table 4.
Genes with increased expression in orbital fibrotic disease (Table 2) in common with genes with increased expression in idiopathic pulmonary fibrosis [9].
| Orbital Adipose | Lung | |||
|---|---|---|---|---|
|
|
||||
| Gene Title | Fold Change* | FDR p-value | Fold Change | Q value |
| anthrax toxin receptor 1 | 1.3928 | 0.0016 | 0.81 | 2.10E-04 |
| 1.2915 | 0.031 | |||
|
| ||||
| cadherin 11, type 2, OB-cadherin (osteoblast) | 1.4538 | 0.0014 | 0.64 | 8.40E-03 |
| 1.3217 | 0.01 | |||
|
| ||||
| calpain 6 | 1.4451 | 0.0406 | 1.96 | 6.70E-04 |
|
| ||||
| collagen triple helix repeat containing 1 | 1.5247 | 0.0265 | 8.41 | 2.20E-07 |
|
| ||||
| collagen, type I, alpha 2 | 1.5119 | 0.0016 | 1.21 | 4.90E-03 |
|
| ||||
| collagen, type VIII, alpha 2 | 1.323 | 0.0098 | 1.44 | 2.60E-07 |
|
| ||||
| dihydropyrimidinase-like 3 | 1.2101 | 0.0406 | 1 | 1.30E-04 |
|
| ||||
| fibronectin 1 | 1.5643 | 0.0015 | 2.25 | 2.10E-04 |
| 1.5108 | 0.0016 | |||
| 1.5068 | 0.0016 | |||
| 1.4716 | 0.0036 | |||
| 1.4095 | 0.0077 | |||
|
| ||||
| fibronectin type III domain containing 1 | 1.6789 | 0.0406 | 14.44 | 2.80E-08 |
|
| ||||
| immunoglobulin heavy constant alpha 1; immunoglobulin heavy constant alpha 2 (A2m marker); immunoglobulin heavy constant delta; immunoglobulin heavy constant gamma 1 (G1m marker); immunoglobulin heavy constant gamma 3 (G3m marker); immunoglobulin heavy constant gamma 4 (G4m marker); immunoglobulin heavy constant mu; immunoglobulin heavy variable 4–31 | 1.4915 | 0.0252 | 3.61 | 9.30E-03 |
|
| ||||
| immunoglobulin heavy locus; immunoglobulin heavy constant alpha 1; immunoglobulin heavy constant alpha 2 (A2m marker); immunoglobulin heavy constant delta; immunoglobulin heavy constant gamma 1 (G1m marker); immunoglobulin heavy constant gamma 2 (G2m marker); immunoglobulin heavy constant gamma 3 (G3m marker); immunoglobulin heavy constant mu; immunoglobulin heavy variable 4–31 | 1.2907 | 0.0406 | 10.89 | 5.40E-08 |
|
| ||||
| immunoglobulin heavy constant gamma 1 (G1m marker); immunoglobulin heavy constant mu | 1.5036 | 0.0415 | 4.84 | 6.60E-03 |
| 1.4027 | 0.0406 | |||
| 1.3756 | 0.0382 | |||
|
| ||||
| latexin | 1.3505 | 0.0489 | 2.25 | 4.90E-06 |
|
| ||||
| lumican | 1.6664 | 6.00E-04 | 2.25 | 6.50E-04 |
|
| ||||
| sulfatase 1 | 1.3868 | 0.0449 | 7.29 | 3.60E-10 |
|
| ||||
| thrombospondin 1 | 1.4609 | 0.0252 | 0.81 | 4.00E-02 |
| 1.4199 | 0.0406 | |||
| 1.4172 | 0.0449 | |||
|
| ||||
| TIMP metallopeptidase inhibitor 1 | 1.2909 | 0.0406 | 0.81 | 7.60E-03 |
*
Based on a linear trend