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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: J Hepatol. 2016 Mar 14;65(1):213–221. doi: 10.1016/j.jhep.2016.03.004

Figure 5. Pathological potentials in EV research.

Figure 5

EV research could contribute to liver pathology. Major EVs, exosomes and microvesicles can be isolated by centrifugation from various body fluids. Circulating EV cargoes could be analyzed as disease-specific biomarkers leading to a novel non-invasive diagnostic method. EVs can be taken up by other liver cells and modify microenvironment by enhancing cell proliferation and migration, and this could lead to better understanding of pathophysiology of liver disorders. EVs could also be used as a tumor suppressor suggesting that EVs have a therapeutic potential to treat liver cancer.