Table 1.

Selected studies for diagnosis of liver disease using human circulating miRNAs

Biomarker	Sample	Cases	Controls	Control condition	Sensitivity	Specificity	AUC	Regulation	[Ref.]
HCC
miR-143	Serum	95	127	Healthy	73	83	0.795	Up	[45]
miR-215	Serum	95	127	Healthy	80	91	0.816	Up	[45]
miRNA panel1	Serum	112	42	Healthy	82	98	0.949	Up/Down	[46]
miR-221	Serum	30	60	Non-HCC	87	40	0.655	Up	[47]
miRNA panel2	Serum	27	135	Non-HCC	70	80	0.752	Up	[48]
miR-101	Serum	67	61	Cirrhosis	96	90	0.976	Down	[49]
miRNA panel3	Serum	103	78	Cirrhosis	82	85	0.892	Up/Down	[50]
miRNA panel4	Plasma	67	82	HBV	86	64	0.802	Up	[51]
CCA
miRNA panel5	Bile	46	50	Healthy	67	96	N/A	Up	[52]
miR-192	Serum	51	32	Healthy	74	72	0.803	Up	[53]
miRNA panel6	Urine	22	21	Healthy	82	71	0.849	Up	[54]
HBV
miRNA panel7	Plasma	100	100	Cirrhosis	80	70	0.858	Up	[55]
DILI
miRNA panel8	Plasma	41	40	Non-DILI	90	90	0.96	Up/Down	[56]

Notes:

¹miR-19a, -195, -192, -146a;

²miR-29a, -29c, -133a, -143, -145, -192, -505;

³miR-122, -1228, -141-3p, -192, -199a, -206, -26a, -433-3p;

⁴miR-20a, 25-3p, -30a, -92a-3p, -132-3p, -185, -320a, -324-3p;

⁵miR-191, -486-3p, -1274b, -16, -484;

⁶miR-192, -21;

⁷miR-18a, -21, -29c-3p, -106b, -122, -185;

⁸miR-382, -483-3p, -125a, -1290, -378i, -449b-3p, -151a-3p, -1915, -652, -27a-3p, -122, -151a, -151b, -885, -26a, -4783-3p, -2861