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. Author manuscript; available in PMC: 2017 Jul 1.

Published in final edited form as: J Am Acad Dermatol. 2016 Mar 4;75(1):69–76.e2. doi: 10.1016/j.jaad.2016.02.1146

Histopathologic examination of a KD-associated psoriasiform lesion, demonstrating (A) psoriasiform hyperplasia and focal thinning of the suprapapillary plates (H&E, 40x), with (B) mounds of parakeratosis, neutrophils, and serum in the cornified layer (H&E, 200x). Immunohistochemistry showed (C) suprabasilar keratin 16 staining (100x) and (D) increased Ki-67 antigen expression in the lower epidermis (40x). Non-psoriatic skin typically has keratin 16 staining only in the basal cells and the tips of rete ridges, while Ki-67 expression is scant and at most present at the basal layer.^9–11,21

Histopathologic examination of a KD-associated psoriasiform lesion, demonstrating (A) psoriasiform hyperplasia and focal thinning of the suprapapillary plates (H&E, 40x), with (B) mounds of parakeratosis, neutrophils, and serum in the cornified layer (H&E, 200x). Immunohistochemistry showed (C) suprabasilar keratin 16 staining (100x) and (D) increased Ki-67 antigen expression in the lower epidermis (40x). Non-psoriatic skin typically has keratin 16 staining only in the basal cells and the tips of rete ridges, while Ki-67 expression is scant and at most present at the basal layer.^9–11,21