Table III.
Comparison of histologic findings of skin biopsies from Kawasaki disease-associated psoriasiform eruptions versus those of typical plaque or guttate psoriasis and other psoriasiform dermatitides (such as chronic spongiotic dermatitides with a psoriasiform pattern or psoriasiform drug eruptions)
| KD + psoriasis (n = 4) | Typical plaque and guttate psoriasis (n = 11) | P-value* | Psoriasiform dermatitis (n = 5) | P-value* | |
|---|---|---|---|---|---|
| Serous exudate or crusting | 4 (100%) | 1 (9%) | 0.004 | 1 (20%) | 0.05 |
| Bacteria in the cornified layer | 2 (50%) | 0 (0%) | 0.06 | 1 (20%) | 0.52 |
| Hyperkeratosis | 4 (100%) | 8 (73%) | 0.52 | 5 (100%) | -- |
| Parakeratosis | 4 (100%) | 11 (100%) | --- | 5 (100%) | -- |
| Neutrophils in cornified layer | 3 (75%) | 7 (64%) | 1 | 5 (100%) | 0.44 |
| Munro microabscesses | 2 (50%) | 6 (55%) | 1 | 1 (20%) | 0.52 |
| Regular epidermal hyperplasia | 2 (50%) | 7 (64%) | 1 | 1 (20%) | 0.52 |
| Irregular epidermal hyperplasia | 2 (50%) | 4 (36%) | 1 | 4 (80%) | 0.52 |
| Elongated rete ridges | 4 (100%) | 7 (64%) | 0.52 | 4 (80%) | 1 |
| Thinning suprapapillary plates | 4 (100%) | 6 (55%) | 0.23 | 3 (60%) | 0.44 |
| Diminished granular cell layer | 4 (100%) | 11 (100%) | --- | 5 (100%) | -- |
| Neutrophils in epidermis | 3 (75%) | 3 (27%) | 0.24 | 0 (0%) | 0.05 |
| Kogoj micropustules | 0 (0%) | 3 (27%) | 0.52 | 0 (0%) | -- |
| Increased proliferation index | 4 (100%) | 8 (73%) | 0.52 | 5 (100%) | -- |
| Epidermal spongiosis | 4 (100%) | 10 (91%) | 1 | 4 (80%) | 1 |
| Dilated blood vessels in dermis | 3 (75%) | 9 (82%) | 1 | 4 (80%) | 1 |
| Tortuous capillaries | 3 (75%) | 8 (73%) | 1 | 3 (60%) | 1 |
| Vasculitis | 0 (0%) | 0 (0%) | --- | 0 (0%) | -- |
| Lymphocytic infiltrate | 4 (100%) | 11 (100%) | --- | 5 (100%) | -- |
| Eosinophilic infiltrate | 1 (25%) | 2 (18%) | 1 | 3 (60%) | 0.52 |
| Dermal edema | 0 (0%) | 4 (36%) | 0.52 | 0 (0%) | -- |
| Vertically oriented collagen bundles | 2 (50%) | 1 (9%) | 0.15 | 3 (60%) | 1 |
| Apoptotic keratinocytes | 0 (0%) | 0 (0%) | --- | 2 (40%) | 0.44 |
*
P-values are in comparison to KD-associated psoriasiform (KD + psoriasis) eruptions