Table 1.

Metabolic or cardiovascular phenotypes of Map4k4 knockout models.

Cre/tissue(s) deleted	Metabolic or cardiovascular phenotype	Ref
Ubiquitin-ERT2/whole body (inducible)	↑insulin sensitivity ↓insulin (HFD fed animals)	[33]
Adiponectin/white and brown adipose tissue	none	[33]
Albumin/liver	none	[33]
Myf5/skeletal muscle, brown adipose tissue	↑glucose tolerance ↑insulin sensitivity (HFD fed animals)	[33]
CD4/T-cells	↑glucose ↑insulin ↓glucose tolerance ↓insulin sensitivity (chow fed, lean animals)	[46]
Cdh5(PAC)-ERT2/endothelial cells (inducible)	↓plaque formation (Western diet, ApoE−/− mice)	[31]