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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Neuropharmacology. 2016 Apr 22;108:193–206. doi: 10.1016/j.neuropharm.2016.04.031

Figure 4.

Figure 4

Cell-selective effect of lysosome disruption, to test a possible endocytic pathway role for Golgi accumulation (Marks and Pagano, 2002). A, B. NIH/3T3 cells (fibroblasts) showed chloroquine-sensitive KK-123 accumulation in presumed Golgi. C, D. Neurons showed no reduction in KK-123 labeling with the same protocol and in fact a slight increase in labeling intensity. For quantification of fluorescence intensity, regions of interest were placed just outside the nucleus. N = 20–25 cells in 4–5 independent platings.