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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Neuropharmacology. 2016 Apr 13;108:316–323. doi: 10.1016/j.neuropharm.2016.04.013

Fig. 1.

Fig. 1

The effect of tozasertib on the neurobehavioral function and brain edema at 24 and 72 hours after SAH. At 24 hours after SAH: A, when compare with Sham group, SAH reduced modified Garcia score and tozasertib at lower (1μg) but not higher (5μg) concentration improved neurological function. C, When compare with Sham, SAH reduced beam balance score and tozasertib at lower (1μg) but not higher (5μg) concentration improved beam balance score. E, SAH increased brain water content and tozasertib at both low (1μg) and high (5μg) concentrations reduced brain water content, but tozasertib (5μg) failed to significantly reduced brain water content in right hemisphere.

At 72 hours after SAH: B, When compare with Sham group, SAH reduced modified Garcia score and tozasertib at lower (1μg) but not higher (5μg) concentrations improved neurological function. D, When compare with Sham, SAH reduced beam balance score and tozasertib at lower (1μg) and higher (5μg) concentrations failed to improve beam balance score. F, SAH increased brain water content and tozasertib at both low (1μg) and high (5μg) concentrations reduced brain water content. *p<0.05 vs sham, #p<0.05 vs SAH/SAH+vehicle.