Plot shows the average maximum cross-sectional area of the histotripsy liver lesions measured over the course of the experiment. The area of the hematoma and granulation tissue components of the lesion, as well as the total lesion cross-sectional area, were compared for rats euthanized after day 0, 3, 7, 14, and 28. Following an increase in the maximum cross-sectional area between day 0 and 3, there was a rapid reduction in lesion size over the remainder of the study. All differences in lesion size were significant (p<0.05).