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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: J Immunol. 2016 May 23;197(1):97–107. doi: 10.4049/jimmunol.1502566

Figure 2. RegIIIγ inhibits pulmonary type 17 immunity by modulating intestinal microbiota.

Figure 2

B6 Jackson (black bars) or RegIIIγ−/− mice (white bars) were infected with A. fumigatus via o.p. aspiration. A. Lung gene expression on day 2 normalized to Hprt (n=5). B. The percent of IL-17 producing cells within individual T cell populations one month following infection (n=3-4). C and D. Mice on vancomycin drinking water for one month or normal water were adoptively transferred with OT-II cells, followed by o.p. immunization with OVA plus cholera toxin. One week later, lung cells were restimulated and stained for intracellular IL-17. C. Total numbers of lung-resident OT-II T cells (CD4+ TCR Vα2+). D. Total numbers of IL-17 producing OT-II CD4 T cells. Data in C and D are combined from two experiments with n=6-8. In one experiment, vancomycin was combined with neomycin, metronidazole and ampicillin.