Table 1.
Test (males, age P75-P165) | Wild type (n) | AS-PKCε (n) | P value |
---|---|---|---|
Weight (g) at age P90-P120 | 27.76 ± 0.92 (10) | 26.43 ± 0.56 (7) | 0.289 |
Wire suspension fall latency (sec) | 111.7 ± 30.7 (10) | 74.3 ± 37.6 (7) | 0.450 |
Accelerating rotarod fall latency (sec) | 56.1 ± 4.8 (19) | 64.1 ± 4.2 (7) | 0.350 |
Open field total distance (cm) | 6292 ± 462.9 (8) | 5532 ± 733.5 (7) | 0.319 |
Open field % time in center | 22.4 ± 3.9 (8) | 21.8 ± 4.6 (7) | 0.929 |
Elevated plus maze (5 min) | |||
% Open time | 41.0 ± 9.4 (10) | 38.3 ± 10.9 (7) | 0.858 |
% Open entries | 43.9 ± 5.5 (10) | 43.4 ± 7.6 (7) | 0.959 |
# Closed entries | 11.9 ± 1.1 (10) | 15.0 ± 2.0 (7) | 0.158 |
Hot plate latency at 56°C (sec) | 5.80 ± 0.27 (8) | 6.01 ± 0.34 (7) | 0.640 |