Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cell-of-origin for OS. The figure shows the most relevant cell types present in the bone microenvironment. MSCs, represented in a perivascular niche, and their derived cell types along the osteogenic lineage, such as the osteoblasts (OSB), are strong candidates to acquire the first cancer-promoting mutations and initiate OS formation.
