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. 2016 Jun 16;2016:4536187. doi: 10.1155/2016/4536187

Table 1.

AHR influences HSC characteristics.

Hematopoietic characteristics AHR exon 2 KO mice (Bradfield) [14] AHR exon 3 KO mice (Taconic Biosciences)
Platelet counts NR Increased
WBC count Increased Higher but NS
Granulocyte and monocyte population Reduced Increased but NS
RBC number Reduced No change
Liver weight Reduced Reduced
Spleen weight and cell number Increased Increased
Functional primitive progenitor colonies Increased numbers Increased numbers
LSK cells Increased Increased
LSK cell proliferation Higher Higher
Cell cycle status of LSK cells Reduced G0/G1 phase
Increased G2/M phase
Reduced G0/G1 phase
Increased G2/M phase
LTHSC in BM NR Higher
Increased self-renewal of LTHSC (serial transplantation) ND Higher
Mesenchymal stem cells in endosteal niche ND Higher
Survival rate Reduced Reduced
Gene expression changes Mtor (↑) Cebpε (↑) Gfi1 (↓) Hes1 (↑) Stra13 (↓) Mtor (↑) Cebpε (↑) Gfi1 (↓) Hes1 (↑) Stra13 (↓)

The table depicts the difference and similarities between the two different strains of AHR-KO mice models (NR = not recorded, ND = not done, NS = not significant, (↑) = upregulation, and (↓) = downregulation).