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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Neurobiol Aging. 2016 May 2;44:185–196. doi: 10.1016/j.neurobiolaging.2016.04.019

Figure 3. Tau-immunostaining in the neocortices of patient with AD (AD2; A) and a 23-year old squirrel monkey (Ss4; B, C).

Figure 3

Panels A and B depict the superior temporal gyrus stained using antibody MC1 to aggregated tau; note the general absence of immunoreactive neurons in the aged squirrel monkey (B) (the cortical surface is to the upper right in both panels). Panel C depicts a rare cortical cell that is immunoreactive with antibody CP13 to hyperphosphorylated tau in squirrel monkey Ss4. Occasional tau-immunoreactive neurons and neurites occur in senescent squirrel monkeys, but AD-like tauopathy has not yet been demonstrated in any aged monkey. Scale bars = 250μm in B (applies also to A) and 50μm in C.