Table 1. Factors influencing APAP-related hepatotoxicity.

Factors	Clinical implications
Dose and pattern of use	↑ APAP toxicity with acute, high doses
EtOH	↓ APAP toxicity with acute EtOH ingestion
	↑ APAP toxicity with chronic EtOH ingestion
Herbs and medications	↑ APAP toxicity with impedance of hepatic glucouronidation
Age and genetic factors	↑ APAP toxicity with advancing age and impaired glucouronidation
Nutritional status	↑ APAP toxicity in malnourished patients
Chronic liver disease	↑ APAP toxicity, especially in chronic EtOH abuse

Abbreviations: APAP, acetaminophen; EtOH, ethyl alcohol.