Table 2.
The coumarin content of the daily dosage from the information leaflet inserted in the package of each Kampo preparation and for cinnamon bark.
| Cinnamon bark content (g/day) | Coumarin content (mg/day) | Coumarin content (mg/g of cinnamon bark) | n | |
|---|---|---|---|---|
| Cinnamon bark | 4.0 | 12.07 | 3.02 | 1 |
| Keishibukuryogankayokuinin (TJ-125) | 4.0 | 5.63 ± 0.94 | 1.41 ± 0.24 | 3 |
| Mokuboito (TJ-36) | 3.0 | 4.00 | 1.33 | 1 |
| Keishibukuryogan (TJ-25) | 3.0 | 2.92 ± 0.09 | 0.97 ± 0.03 | 3 |
| Ryokeijutsukanto (TJ-39) | 4.0 | 2.80 ± 0.96 | 0.70 ± 0.24 | 3 |
| Goreisan (TJ-17) | 1.5 | 2.48 ± 0.07 | 1.65 ± 0.05 | 3 |
| Nyoshinsan (TJ-67) | 2.0 | 2.32 | 1.16 | 1 |
| Kakkonto (TJ-1) | 2.0 | 2.00 ± 0.07 | 1.00 ± 0.03 | 3 |
| Kakkonkajutsubuto (S-07) | 2.0 | 1.80 ± 0.17 | 0.90 ± 0.09 | 3 |
| Saireito (TJ-114) | 2.0 | 1.15 | 0.57 | 2 |
| Saikokeishikankyoto (N11) | 3.0 | 1.13 | 0.38 | 1 |
| Keishininjinto (TJ-82) | 4.0 | 1.09 ± 0.54 | 0.27 ± 0.14 | 3 |
| Saikokeishito (N10) | 2.5 | 1.03 | 0.41 | 1 |
| Saikokeishito (TJ-10) | 2.0 | 0.86 ± 0.20 | 0.43 ± 0.10 | 3 |
| Saikokeishikankyoto (TJ-11) | 3.0 | 0.79 ± 0.05 | 0.26 ± 0.02 | 3 |
| Saikokaryukotsuboreito (TJ-12) | 3.0 | 0.69 ± 0.04 | 0.23 ± 0.01 | 3 |
| Saikokaryukotsuboreito (N12) | 3.0 | 0.66 | 0.22 | 1 |
| Hachimijiogan (TJ-7) | 1.0 | 0.65 ± 0.22 | 0.65 ± 0.22 | 3 |
| Keishikaryojutsubuto (SG-18R) | 4.0 | 0.55 ± 0.14 | 0.14 ± 0.03 | 3 |
| Keishikaryukotsuboreito (TJ-26) | 4.0 | 0.51 ± 0.23 | 0.13 ± 0.06 | 3 |
| Shoseiryuto (TJ-19) | 3.0 | 0.48 ± 0.22 | 0.16 ± 0.07 | 3 |
| Keishikajutsubuto (TJ-18) | 4.0 | 0.46 | 0.11 | 2 |
| Maoto (TJ-27) | 4.0 | 0.41 ± 0.03 | 0.10 ± 0.01 | 3 |
| Kumibinroto (N311) | 3.0 | 0.36 ± 0.02 | 0.12 ± 0.01 | 3 |
| Tokikenchuto (TJ-123) | 4.0 | 0.34 ± 0.26 | 0.08 ± 0.07 | 3 |
| Shakanzoto (TJ-64) | 3.0 | 0.26 ± 0.05 | 0.09 ± 0.02 | 3 |
| Keishito (TJ-45) | 4.0 | 0.26 ± 0.01 | 0.06 ± 0.00 | 3 |
| Juzentaihoto (TJ-48) | 3.0 | 0.24 ± 0.04 | 0.08 ± 0.01 | 3 |
| Jidabokuippo (TJ-84) | 3.0 | 0.24 ± 0.04 | 0.08 ± 0.01 | 3 |
| Hachimigan | 1.0 | 0.22 ± 0.02 | 0.22 ± 0.02 | 3 |
| Tokishigyakukagoshuyushokyoto (TJ-38) | 3.0 | 0.15 | 0.05 | 1 |
| Goshakusan (TJ-63) | 1.0 | ND | ND | 2 |
| Goshajinkigan (TJ-107) | 1.0 | ND | ND | 3 |
| Keishikaogito (TY-026) | 4.0 | ND | ND | 3 |
| Mean ± SD | 1.43 ± 0.20 | 0.50 ± 0.06 |
n, number of production lots for HPLC analysis; ND, not detected; The coumarin content and coumarin content included in 1 g of cinnamon bark are shown as mean ± SD for n = 3, mean for n = 2, and the measured value for n = 1.