Table 3.
Diagnostic performance for ultrasound-based elastography methods for the detection of liver fibrosis.
| Study | Aetiology | AUROC for F > 2 (95%CI) | Cutoff for F2 | Sensitivity (%) | Specificity (%) | AUROC for F4 (95%CI) | Cutoff for F4 | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|---|---|---|---|---|
| TE | kPa | kPa | |||||||
| Talwalkar et al., 2007 | All | 0.87 (0.83–0.91) | – | 70.0 (67.0–73.0) | 84.0 (81.0–87.0) | 0.96 (0.94–0.97) | – | 87.0 (84.0–90.0) | 91.0 (89.0–92.0) |
| Friedrich-Rust et al., 2008 | All | 0.84 (0.82–0.86) | 7.7 | – | – | 0.94 (0.93–0.95) | 13.0 | – | – |
| Stebbing et al., 2010 | All | – | 7.7 | 71.9 (71.4–72.4) | 82.4 (81.9–82.9) | – | 15.1 | 84.5 (84.2–84.7) | 94.7 (94.3–95.0) |
| Tsochatzis et al., 2011b | All | – | – | 79.0 (74.0–82.0) | 78.0 (72.0–83.0) | – | – | 83.0 (79.0–86.0) | 89.0 (87.0–91.0) |
| Shaheen et al., 2007 | HCV | 0.83 (0.03–1.00) | 8.0 | 64.0 (50.0–76.0) | 87.0 (80.0–91.0) | 0.95 (0.87–0.99) | 12.5 | 85.6 (77.8–91.0) | 93.2 (90.2–95.3) |
| Chon et al., 2012 | HBV | 0.859 (0.857–0.860) | 7.9 | 74.3 | 78.3 | 0.929 (0.928–0.929) | 11.7 | 84.6 | 81.5 |
| pSWE/ARFI | m/s | m/s | |||||||
| Friedrich-Rust et al., 2012 | All | 0.87 | 1.34 | 79.0 | 85.0 | 0.93 | 1.80 | 92.0 | 86.0 |
| Nierhoff et al., 2013 | All | 0.84 (0.80–0.87) | 1.35 | – | – | 0.91 (0.89–0.94) | 1.87 | – | – |
| Bota et al., 2013b | All | 0.85 (0.82–0.88) | 1.30 | 74.0 (66.0–80.0) | 83.0 (75.0–89.0) | 0.93 (0.91–0.95) | 1.80 | 87.0 (79.0–92.0) | 87.0 (81.0–91.0) |
| Guo et al., 2015 | All | 0.85 | – | 76.0 (73.0–78.0) | 80.0 (77.0–83.0) | 0.94 | – | 88.0 (84.0–91.0) | 83.0 (81.0–84.0) |
| Liu et al., 2015 | NAFLD | 0.90 (0.84–0.96) | – | 80.2 (75.8–84.2) | 85.2 (80.8–89.0) | – | – | – | – |
Diagnostic performance for transient elastography (TE) and point shear wave elastography/acoustic radiation force impulse (pSWE/ARFI) for F > 2 and F4 presented in a number of meta-analyses.