Table 4.
Incidence and total of adverse events and post-operative complications
| Trial | Treatment | N | Patients with grade 3–4 AEs pre-op | Total grade 3–4 AEs pre-op | Patients with grade 3–4 AEs post-op | Total grade 3–4 AEs post-op | Post-operative complications |
|---|---|---|---|---|---|---|---|
| Primrose 2014 | FOLFOX/Surgery/FOLFOX | 128 | 54/134 (40%) | 64 | 22/104 (21%) | 25 | 23/100 (23%) |
| FOLFOX + CET/Surgery/FOLFOX + CET | 129 | 64/137 (47%) | 83 | 29/105 (28%) | 37 | 16/98 (16%) | |
| Nordlinger 2013 | Surgery | 182 | NA | NA | NA | NA | 27/170 (16%)* |
| FOLFOX/Surgery/FOLFOX | 182 | 71/141 (42%) | 116 | 68/115 (59%) | 132 | 40/159 (25%)* | |
| Ychou 2009 | Surgery/FUFA | 153 | NA | NA | 45/152 (30%)* | 43 | NA |
| Surgery/FOLFIRI | 153 | NA | NA | 73/154 (47%)* | 92 | NA | |
| Portier 2006 | Surgery | 85 | NA | NA | NA | NA | NA |
| Surgery/FUFA | 86 | NA | NA | 20 (25%) | 27 | NA |
Abbreviations: AEs, adverse events; pre-op, pre-operative; post-op, post-operative; NA, not applicable; NR, not reported.
*p < 0.05.