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. 2016 May 18;6(2):26–35.

Figure 1.

Figure 1

A. Effects of capsaicin (natural Na+ blocker) on collagen type I ECM deposition by cultured human skin fibroblasts (* indicates significance of p≤0.005 between ascorbate and ascorbate + capsaicin ECM collagen l deposition); B. Effects of ditiazem (Ca++ blocker) on collagen type I ECM deposition by human skin fibroblasts (* indicates significance of p<0.0001 between ascorbate vs ascorbate and ditiazem ECM collagen l deposition); C. Effects of lidocaine (Na+ blocker) on collagen type I ECM deposition by cultured human skin fibroblasts (* indicates significance of p<0.0001 between ascorbate and ascorbate + lidocaine ECM collagen l deposition; ** indicates significance of p≤0.01 between ECM collagen l deposition at increased concentrations of lidocaine compared to control); D. Effects of nifedipine (Ca++ blocker) on collagen type I ECM deposition by cultured human skin fibroblasts (* indicates significance of p<0.0001 between ascorbate and ascorbate + nifedipine ECM collagen l deposition; ** indicates significance of p≤0.05 between ECM collagen l deposition at increased concentrations of nifedipine compared to control); E. Effects of quinidine (Na+ blocker) on collagen type I ECM deposition by cultured human skin fibroblasts (* indicates significance of p≤0.006 between ascorbate and ascorbate + quinidine ECM collagen l deposition); F. Effects of verapamil (Ca++ blocker) on collagen type I ECM deposition by cultured human skin fibroblasts (* indicates significance of p≤0.002 between ascorbate and ascorbate + verapamil ECM collagen l deposition).