. 2016 Jun 1;7(2):95–104.

Table 3.

Association between Six Known GWA Loci for Smoking Addition and Risk for Smoking Relapse and Quit Attempt in LSC

Gene name	Locus	SNP	Test SNP	R²	Minor	MAF^a	RR^b			RQ^b

							OR	95% CI	P Value	OR	95% CI	P Value
CHRNA3, CHRNA5	15q25	rs1051730	Same	1	T	0.36	0.92	0.74, 1.15	0.46	1.14	0.94, 1.39	0.18
		rs16969968	Same	1	A	0.36	0.94	0.76, 1.18	0.61	1.15	0.95, 1.40	0.15
		rs55853698	rs2036527	1	T	0.37	0.90	0.72, 1.12	0.34	1.06	0.87, 1.29	0.55
		rs6495308	Same	1	C	0.22	1.35	1.12, 1.63	0.0017	0.93	0.80, 1.08	0.34
CHRNB3	8p11	rs6474412	rs4950	1	C	0.22	0.90	0.69, 1.17	0.44	1.01	0.81, 1.27	0.91
		rs13280604	rs4950	1
Near PPP1R3C	10q23	rs1329650	Same	1	A	0.27	0.87	0.68, 1.11	0.27	0.86	0.70, 1.07	0.17
		rs1028936	Same	1	C	0.18	0.88	0.66, 1.18	0.40	0.86	0.67, 1.10	0.22

EGLN2, CYP2A6	19q13	rs3733829	Same	1	C	0.38	0.97	0.78, 1.22	0.81	0.92	0.76, 1.12	0.41
CYP2A6, CYP2B6		rs7937	Same	1	C	0.43	1.00	0.80, 1.25	0.99	1.03	0.85, 1.25	0.75
		rs1801272	NG
		rs4105144	NG
		rs7260329	Same	1	A	0.31	1.12	0.89, 1.42	0.33	1.01	0.83, 1.23	0.95
BDNF	11p14	rs6265	Same	1	A	0.18	0.80	0.61, 1.06	0.12	1.16	0.90, 1.49	0.24
		rs1013442	rs10734394	1	G	0.23	0.77	0.60, 1.00	0.052	1.17	0.93, 1.46	0.18
		rs4923457	rs4074134^c	1	A	0.20	0.84	0.68, 1.03	0.092	0.95	0.81, 1.12	0.55
		rs4923460	rs4074134	1
		rs4074134	Same	1
		rs1304100	rs10734394	0.96
		rs6484320	rs7103411^c	0.87	C	0.20	0.83	0.68, 1.02	0.071	0.97	0.82, 1.14	0.71
		rs879048	rs4074134	1
DBH	9q34	rs3025343	rs3025316	0.93	C	0.11	0.92	0.64, 1.31	0.63	0.80	0.60, 1.08	0.14

Abbreviations: CI, confidence interval; GWA, genome-wide association; MAF, minor allele frequency; OR, odds ratio; RQ, retrospective quit; RR, retrospective relapse; SNP, single nucleotide polymorphism.

MAF in 1163 NHWs.

Adjusted for age, sex, packyears, age start smoking, childhood Respiratory illness, Hispanic ethnicity, education, and not living with smokers during adulthood. Sample size is 651 RRs and 363 non-RRs and 714 RQs and 422 non-RQs for all 15 SNPs except for rs6495308, rs4074134, and rs7103411 that included additional 346 RRs and 266 non-RRs and 612 RQs and 451 non-RQs. RR: retrospective relapse. RQ: retrospective quit.

rs4074134 and rs7103411 are in high LD (r²=0.91).