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. 2016 Jun 20;6:28356. doi: 10.1038/srep28356

Table 3. Coding variants associated with QT interval in AA ARIC subjects.

Chr:Position (hg19) Gene cDNA change Protein change MAF Beta P PhyloP score Protein domain ExAC allele count
9:35711334 TLN1 c.A3937G p.S1313G 0.00026 15.81 3.60 × 10−60 3.48 – 2/121374
2:179455331 TTN c.C61121T p.P20374L 0.00053 8.85 2.26 × 10−37 6.39 – 2/119910
2:179447784 TTN c.C65746T p.R21916W 0.00026 4.98 5.87 × 10−07 0.65 IGC2 13/113940
3:38645514 SCN5A c.G1579A p.G527R 0.00026 4.33 1.48 × 10−05 3.93 – 4/90200
2:179528396 TTN c.C36490A p.P12164T 0.00026 4.10 4.03 × 10−05 −0.49 IG 7/117870
2:179447313 TTN c.C65870T p.P21957L 0.00026 3.90 9.92 × 10−05 6.22 FN3 –
2:179428672–179428673 TTN c.82186_82187CA > GT p.Q27396V 0.00026 3.79 0.00015 4.74, 5.31 FN3 1/120622, 1/120618
2:179451505 TTN c.G64123A p.V21375M 0.00026 3.79 0.00015 6.37 FN3 1/120562
2:179497341 TTN c.G43392A p.M14464I 0.00026 3.79 0.00015 1.68 IGC2 3/120562
2:179434555 TTN c.G76304A p.C25435Y 0.00026 3.62 0.00029 4.48 IGC2 1/120440
2:179440480 TTN c.T70379G p.L23460R 0.00053 2.52 0.00036 5.13 FN3 –