Figure 2.

HIV-1 Tg and WT rats were placed in an open-field maze during the rats’ light and dark cycles. The distance traveled and the percentage of time the rats spent in the center of the maze were measured. HIV-1 Tg rats traveled a decreased distance compared to WT controls in the light cycle (A). Male (C) and female (A) rats traveled an increased distance in the dark cycle compared to the light cycle. The percentage of time rats spent in the center was unaffected by stress or transgene in males (D). Female Tg rats spent a decreased percentage of time in the center compared to WT female rats during the light cycle (B). Male (D) and female (B) rats spent an increased percentage of the time in the center during the dark cycle. Data are presented as mean ± SEM. & denotes the main effect of time. *Denotes a main effect in a t-test collapsed across stress. α = 0.05.