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Semi-logarithmic concentration–time profile for unbound cefazolin in microdialysate and plasma samples of all patients who received one dose of cefazolin. The horizontal lines indicate various concentration targets and associated surgical site infection pathogen(s). The vertical line indicates 240 min, the time when cefazolin was dosed again for those patients receiving two doses. E., Escherichia; K., Klebsiella; MD, microdialysate; MSSA, meticillin-sensitive Staphylococcus aureus.
