FIGURE 8.

Immunohistochemical assessment of conformational tau antibody TOC1 and phosphorylated tau antibody RZ3 (pThr231) in an hTau mouse model of chronic repeated traumatic brain injury (r-TBI). (A, B) There is an increase in anti-TOC-1 immunostaining in the cortex of injured (r-TBI) compared with sham animals. (C, D) There was also an increase in pTau Thr231 (RZ3) immunostaining in pyramidal neurons in layers II-IV of the cortex of injured versus sham animals. High-power micrographs insets B and D were taken from injured animals (white boxes).