FIGURE 2.

Effect of forskolin treatment on behavior and sociability impairments. (A, B) APP/PS1 mice were treated for with forskolin in 1% carboxymethylcellulose (CMC) or with CMC alone for 10 days. They were assessed for nesting behavior along with untreated nontransgenic mice. There was no significant difference between the forskolin-treated and control groups at day 1 (n = 6/group) (A). At day 10 there was a significant increase in nesting score in the forskolin-treated compared with control mice (n = 6/group) (p < 0.05) (B). (C) Tested mice spent more time with the stranger 1 mice than empty side; forskolin-treated mice spent more time versus controls (p < 0.01). (D) Times spent in the chamber were not significantly different between control and forskolin group for the preference for social novelty test.