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. 2016 May 31;75(7):618–627. doi: 10.1093/jnen/nlw043

FIGURE 4.

FIGURE 4

Effect of forskolin on microglia. (A–D) Representative photomicrographs of coronal sections through cortex and hippocampus show reduction of microglial activation following treatment with forskolin. Many Iba-1-positive cells are seen in the cortex (A) and hippocampus (C) of control mice. Most of the Iba-1-positive microglia appear to surround Aβ plaques. There are fewer Iba-1-positive cells in the cortex (B) of the forskolin-treated group. There were large numbers of Iba-1-positive cells in the hippocampus, in both control (C) and forskolin-treated group (D). (E, F) The IR area percentage of Iba-1 staining (E) was reduced in the forskolin-treated group (n = 6/group) and in the hippocampus (F). **p < 0.01; *p < 0.05.