Table 1. Functional program of gene clusters suggested by Ingenuity Pathway Upstream Regulator Analysis.

Regulators in bold contribute to the functional theme.

Cluster	Functional Theme	Predicted Upstream Transcriptional Regulators
1	Cytokine Signaling	IFNG, IL5, IL27, CD38, IL10, MYC, STAT3, DYSF, REL, IL4
2	Growth and proliferation	MYCN, MYC, IL3, PRKAG3, IL4, GNRH2, IFNG
3	Lymphopoiesis, Cell cycle	TCF3, CDKN1A, CHEK1, YY1, CDKN2A, TBX2, TADA3, SNAI1
4	IL-12 Signaling	LXR, IL12
5	Cell cycle	TP53, E2F4, CDKN1A, RB1, CDKN2A, E2F1, E2F2, EP400, CSF2, BX2
6	Inflammatory signaling, Homeobox genes	IL2, NFKBIB, DMD, FOXO1, HOXA7, HOXA9, FFAR1, DLG1, BTNL2, RELA
7	Growth	IGFBP2, BRCA1, PTEN, AKT, NGFR
8	Growth, Myelopoeisis	Map4K4, MYC, SPI1, LIPE, CEBPA, HSF2, ESRRG, AK1, CSF3, KRAS
9	T- versus B-cell specification	IL2, TCR, PAX5, SMARCC1, TP53, IFNG, IL7, TCF3, EBF1, TNF
10	Myelo- and lymphopoietic factors	CEBPA, GATA1, SRF, TGFB1, RNF20, ETS1, GATA2, PPARA, NR5A1, IL4