Table 1.
Demographic Information for Matched Subjects from Study 1 (ABIDE Database) and Study 2 (In-House Database)
| Study 1 | Study 2 | |||||
|---|---|---|---|---|---|---|
| ASD | TD | p | ASD | TD | p | |
| Participants matched after preprocessing (n) | 76 | 76 | — | 32 | 32 | — |
| Number of participants from each site | 7a,15b,5c,15d,7e,27f | 7a,14b,10c,9d,8e,28f | — | 32a | 32a | — |
| Age in years (mean ± std, range) | 16.1 ± 4.9, 7–29.9 | 15.8 ± 4.5, 8.0–29.9 | 0.6 | 14.3 ± 2.4, 9.5–17.9 | 13.5 ± 2.7, 8–17.5 | 0.18 |
| Sex | 9 female | 12 female | — | 4 female | 5 female | — |
| Handedness (R, L) | 62, 14 | 64, 12 | — | 28, 4 | 28, 4 | — |
| FIQ | 106.6 ± 18.1 | 108.1 ± 12.4 | 0.5 | 106.3 ± 18.0 | 109.5 ± 11.1 | 0.4 |
| VIQ | 105.5 ± 19.5 | 109.5 ± 12.5 | 0.15 | 104.8 ± 19.9 | 108.2 ± 11.3 | 0.4 |
| PIQ | 106.2 ± 17.9 | 105.8 ± 13.3 | 0.8 | 105.5 ± 17.8 | 109.2 ± 11.3 | 0.3 |
| Eye status at scan (open, closed, NA) | 68, 2, 6 | 67, 2, 7 | — | 33, 0, 0 | 33, 0, 0 | — |
| Mean root sum of squares of derivatives | ||||||
| All 6 parameters (mean ± std) | 0.044 ± 0.015 | 0.043 ± 0.012 | 0.7g | 0.057 ± 0.026 | 0.056 ± 0.024 | 0.8h |
| Roll | 0.009 ± 0.004 | 0.009 ± 0.002 | 0.3 | 0.011 ± 0.005 | 0.011 ± 0.005 | 0.8 |
| Pitch | 0.017 ± 0.007 | 0.017 ± 0.007 | 0.9 | 0.028 ± 0.015 | 0.025 ± 0.015 | 0.5 |
| Yaw | 0.009 ± 0.003 | 0.010 ± 0.003 | 0.7 | 0.013 ± 0.007 | 0.012 ± 0.006 | 0.6 |
| Displacement (superior/inferior) | 0.024 ± 0.009 | 0.024 ± 0.008 | 0.9 | 0.031 ± 0.015 | 0.032 ± 0.014 | 0.6 |
| Displacement (left/right) | 0.010 ± 0.005 | 0.009 ± 0.003 | 0.4 | 0.009 ± 0.004 | 0.007 ± 0.003 | 0.17 |
| Displacement (anterior/posterior) | 0.013 ± 0.006 | 0.012 ± 0.006 | 0.6 | 0.014 ± 0.009 | 0.013 ± 0.008 | 0.6 |
| Percent time points remaining after censoring | 91.1 ± 6.7 | 91.9 ± 6.4 | 0.4 | 93.3 ± 4.4 | 93.6 ± 4.8 | 0.8 |
| ADOS social (mean ± SD) (N: Number of data available) | 7.7 ± 2.9 (N = 49) | — | — | 7.9 ± 2.8 | — | — |
| ADOS communicative | 3.8 ± 1.6 (N = 49) | — | — | 3.6 ± 1.7 | — | — |
| ADOS repetitive behavior | 2.0 ± 1.6 (N = 48) | — | — | 1.8 ± 1.2 | — | — |
| SRS total | 86.1 ± 35.3 (N = 48) | 22.0 ± 18.1 (N = 36) | 0.000 | 80.0 ± 9.4 | 41.9 ± 5.0 | 0.000 |
a
San Diego State University.
b
University of Michigan: Sample 1.
c
University of Michigan: Sample 2.
d
University of Utah School of Medicine.
e
Yale Child Study Center.
f
NYU Langone Medical Center.
g
p = 0.6 using Kolmogorov–Smirnov test (ks = 0.1). See Supplementary Figure 3 for the histogram of rmsd of all motion parameters.
h
p = 0.38 using Kolmogorov–Smirnov test (ks = 0.2).
ABIDE, Autism Brain Imaging Data Exchange; ASD, autism spectrum disorder; TD, typically developing.