Table 2.
Relationship between FOXP3 and GARP expressions and clinicopathologic parameters in the NACT group
| FOXP3+ Tregs
|
P-value | GARP+ Tregs
|
P-value | |||
|---|---|---|---|---|---|---|
| Low (n=37) | High (n=19) | Low (n=36) | High (n=20) | |||
| Sex | ||||||
| Male | 26 | 10 | 0.196 | 24 | 12 | 0.621 |
| Female | 11 | 9 | 12 | 8 | ||
| Age (years) | ||||||
| <55 | 13 | 7 | 0.900 | 12 | 8 | 0.621 |
| ≥55 | 24 | 12 | 24 | 12 | ||
| Differentiation | ||||||
| Well/moderately | 16 | 4 | 0.104 | 12 | 8 | 0.621 |
| Poorly | 21 | 15 | 24 | 12 | ||
| Invasion depth | ||||||
| T2 | 12 | 4 | 0.376 | 12 | 4 | 0.294 |
| T3/T4 | 25 | 15 | 24 | 16 | ||
| TNM stage | ||||||
| II | 20 | 4 | 0.019 | 20 | 4 | 0.011 |
| III + IV | 17 | 15 | 16 | 16 | ||
| Lymph node metastasis | ||||||
| No | 20 | 8 | 0.401 | 20 | 8 | 0.269 |
| Yes | 17 | 11 | 16 | 12 | ||
| FOXP3+ Tregs | ||||||
| Low | NA | NA | NA | 33 | 4 | 0.000 |
| High | NA | NA | 3 | 16 | ||
| GARP+ Tregs | ||||||
| Low | 33 | 3 | 0.000 | NA | NA | NA |
| High | 4 | 16 | NA | NA | ||
Notes: T2, tumor invasion of muscularis propria; T3, tumor invasion of subserosal connective tissue; T4, tumor invasion of serosal or adjacent structures; well/moderately, well/moderately differentiated carcinoma; poorly, poorly differentiated carcinoma.
Abbreviations: NACT, neoadjuvant chemotherapy; TNM, tumor, node, metastasis; Tregs, regulatory T-cells; NA, no data.